Microorganisms are not visible to the naked eye, yet they can present dangers to products, operators, and consumers. Not only can microorganisms have adverse effects on health, they can also compromise product shelf life, as well as product image, and overall profitability. A robust environmental monitoring program, encompassing testing of personnel, surfaces, and air, will assure aerobiological controls are maintained. Observing regulatory compliance, and incorporating frequent air monitoring, allows threats to be quickly identified and eradicated.